I mostly use Photoshop with my tablet. I want to explore other programs but so far Photoshop gets the job done. I'm not a big fan of traditional art mediums only because of how messy they can be, plus I don't really have room anywhere in my house to put a lot of the supplies.
It depends on what you get. Painting needs a lot of space generally for the room to paint, the canvas, paint tubes, palette, and brushes but if you get colored pencils for example, they don't take up as much space.
My favorite paint will always be acrylics. Then again it's a nice way to break your pockets.
Not to mention the fumes! But yeah, each medium has their positives and negatives. I really should get back to painting - I've got so many painting materials lying around. xD
I've got so many art supplies in general.
I am so not typing anything interesting...